Table 1 Characteristics of direct oral anticoagulants
From: Profiles of direct oral anticoagulants and clinical usage—dosage and dose regimen differences
Dabigatran | Rivaroxaban | Edoxaban | Apixaban | |
|---|---|---|---|---|
Inhibition target | Factor IIa | Factor Xa | Factor Xa | Factor Xa |
Pro-drug | Yes | No | No | No |
Liver metabolism | ca. 20 % | ca. 66 % | NR | NR |
Renal excretion rate | 80 % | 36 % | 35 % | 25 % |
Elimination half-life | 14–17 h | 7–11 h | 9–11 h | 10–14 h |
Bioavailability | 6.5 % | 80–100 % | 50 % | 50 % |
Interaction | P-gp | 3A4/2 J2, P-gp | 3A4, P-gp | 3A4, P-gp |
Dosage form | Capsule | Tablet | Tablet | Tablet |