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Table 1 Characteristics of direct oral anticoagulants

From: Profiles of direct oral anticoagulants and clinical usage—dosage and dose regimen differences

  Dabigatran Rivaroxaban Edoxaban Apixaban
Inhibition target Factor IIa Factor Xa Factor Xa Factor Xa
Pro-drug Yes No No No
Liver metabolism ca. 20 % ca. 66 % NR NR
Renal excretion rate 80 % 36 % 35 % 25 %
Elimination half-life 14–17 h 7–11 h 9–11 h 10–14 h
Bioavailability 6.5 % 80–100 % 50 % 50 %
Interaction P-gp 3A4/2 J2, P-gp 3A4, P-gp 3A4, P-gp
Dosage form Capsule Tablet Tablet Tablet
  1. IIa thrombin, Ca. approximately, NR not reported, P-gp p-glycoprotein (inhibitor), 3A4/2J2 cytochrome P450 3A4/2J2 (inhibitor), 3A4 cytochrome P450 3A4 (inhibitor)