|
HACA Study Group 2002 [3]
|
32–34 °C
|
After ROSC at hospital
|
Within 4 h after ROSC
|
External cooling device (TheraKool®) (if the goal was not achieved, ice packs were applied
|
24 h from cooling
|
Midazolam (0.125 mg/kg/h) and fentanyl (0.002 mg/kg/h) for 32 h
|
Pancuronium (0.1 mg/kg) every 2 h for a total of 32 h
|
Passive rewarming (over a period of 8 h)
|
/
|
|
Bernard, et al. 2002 [4]
|
33 °C
|
After ROSC in the ambulance
|
/
|
Ice packs (Coolcare®)
|
12 h after hospital arrival
|
Midazolam (2–5 mg) for 24 h
|
Vecronium (8–12 mg) for 24 h
|
Beginning at 18 h, actively rewarmed for the next 6 h by external warming with a heated-air blanket
|
Usual intensive care
|
|
CoSTR from ILCOR 2010 [1, 2] Guidelines from AHA, ERC 2010 [18, 19]
|
32–34 °C
|
Minutes to hours after ROSC
|
/
|
No single methods has proved to be optimal
|
12–24 h
|
/
|
/
|
/
|
Late hyperthermia (after rewarming post-hypothermia) should be identified and treated
|
|
Nielsen, et al. 2013 [7]
|
33 °C
|
After randomization at hospital, after ROSC
|
As rapidly as possible
|
Ice-cold fluids, ice packs, and intravascular or surface temperature-management devices at the discretions of the sites
|
28 h after randomization
|
Mandated until the end of the intervention period (36 h)
|
/
|
After 28 h, gradual rewarming to 37 °C (0.5 °C/h)
|
For unconscious patients below 37.5 °C until 72 h after cardiac arrest, with the use of fever control measures at the discretion of the sites
|
