Skip to main content

Advertisement

Table 3 Clinical studies using intraoperative hypothermia for neurosurgical procedures

From: Targeted temperature management in traumatic brain injury

Authors and year No. of cases Operative procedure (number) Cooling method Complication Mean target temp (°C) Mean duration of hypothermia (min) Mean rewarming rate(°C/h) Mean rewarming temp (°C) Effectiveness of hypothermia
Baker et al., [67] 1994 30 (Normo 17, Hypo13 ) Elective craniotomy for supratentorial tumor resection (14), aneurysm repair (14), other (2) WB Shivering (Normo 0 case vs Hypo 7 cases, p = 0.002). No severe comp. 34.3 ± 0.4 NR 0.7 ± 0.6 35.8 ± 1.0 NR
Clifton and Christensen, [68] 1992 21 Hypo Aneurysm surgery with elective craniotomy (21) WB No comp. 32.0 NR NR NR NR
Hindman et al, [69] 1999 114 (Normo 57, Hypo 57) SAH clipping (52), unruptured aneurysm clipping (62) AC No significant difference between Normo and Hypo. No severe comp. 33.7 (33.2–34.2) NR NR 35.7 (34.9–36.4) NS
Sato and Yoshimoto [70] 2000 60 (Normo 28, Hypo 32) SAH clipping AC and WB NR 34.0 NR Time, 115 min (45–250 min) 36.2 NR
Steinberg et al., [71] 2004 153 Hypo Elective open craniotomy for unruptured cerebral aneurysm WB(61) vs endo(92) Postoperative infection 4.3 % endo vs 4.9 % WB, NS. No severe comp. in all 33.0 274 1.88 (WB) vs 0.69 (endo) (35–36) NS between WB and endo
Todd et al, [72] 2005 1000 (Normo 501, Hypo 499) SAH clipping AC Postoperative bacteremia (5 % Hypo vs 3 % Normo, P = 0.05, no severe comp. in all. 33.0 (32.5–33.5) 324 ± 120 NR 36.4 ± 1.0 NS
Hindman et al., [73] 2010 441 (Normo 233, Hypo 208) SAH patients undergoing temporary clipping AC NR 33.3–0.8 NR Time, 120 min 36.7–0.5 NS
  1. Normo normothermia, Hypo hypothermia, SAH subarachnoidal hemorrhage, WB water blanket cooling, AC air cooling, endo endovascular cooling, comp complication, NA, not applicable, NR not reported, NS not significant