Table 3 Clinical studies using intraoperative hypothermia for neurosurgical procedures
From: Targeted temperature management in traumatic brain injury
Authors and year | No. of cases | Operative procedure (number) | Cooling method | Complication | Mean target temp (°C) | Mean duration of hypothermia (min) | Mean rewarming rate(°C/h) | Mean rewarming temp (°C) | Effectiveness of hypothermia |
|---|---|---|---|---|---|---|---|---|---|
Baker et al., [67] 1994 | 30 (Normo 17, Hypo13 ) | Elective craniotomy for supratentorial tumor resection (14), aneurysm repair (14), other (2) | WB | Shivering (Normo 0 case vs Hypo 7 cases, p = 0.002). No severe comp. | 34.3 ± 0.4 | NR | 0.7 ± 0.6 | 35.8 ± 1.0 | NR |
Clifton and Christensen, [68] 1992 | 21 Hypo | Aneurysm surgery with elective craniotomy (21) | WB | No comp. | 32.0 | NR | NR | NR | NR |
Hindman et al, [69] 1999 | 114 (Normo 57, Hypo 57) | SAH clipping (52), unruptured aneurysm clipping (62) | AC | No significant difference between Normo and Hypo. No severe comp. | 33.7 (33.2–34.2) | NR | NR | 35.7 (34.9–36.4) | NS |
Sato and Yoshimoto [70] 2000 | 60 (Normo 28, Hypo 32) | SAH clipping | AC and WB | NR | 34.0 | NR | Time, 115 min (45–250 min) | 36.2 | NR |
Steinberg et al., [71] 2004 | 153 Hypo | Elective open craniotomy for unruptured cerebral aneurysm | WB(61) vs endo(92) | Postoperative infection 4.3 % endo vs 4.9 % WB, NS. No severe comp. in all | 33.0 | 274 | 1.88 (WB) vs 0.69 (endo) | (35–36) | NS between WB and endo |
Todd et al, [72] 2005 | 1000 (Normo 501, Hypo 499) | SAH clipping | AC | Postoperative bacteremia (5 % Hypo vs 3 % Normo, P = 0.05, no severe comp. in all. | 33.0 (32.5–33.5) | 324 ± 120 | NR | 36.4 ± 1.0 | NS |
Hindman et al., [73] 2010 | 441 (Normo 233, Hypo 208) | SAH patients undergoing temporary clipping | AC | NR | 33.3–0.8 | NR | Time, 120 min | 36.7–0.5 | NS |