Fig. 1
From: Targeted temperature management in traumatic brain injury
The schema of mechanisms of ischemic/reperfusional (I/R) brain injury and the effective point of hypothermia treatment. The pathology of I/R injury is approximately separated as two mechanisms, i.e., the cell death following cellular dysfunction in ischemic phase and the free radical production in reperfusion phase. The boxed arrow with entered “Hypothermia” means the estimated effective points in I/R cascade