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Table 5 Univariate and multivariate analysis of circulating nucleosomes, C-reactive protein, and creatinine in predicting severe acute pancreatitis

From: Circulating nucleosomes as predictive markers of severe acute pancreatitis

  OR 95 % CI p value
All patients (n = 74)
Univariate analysis    
 Age (year) 0.981 0.948–1.015 0.273
 Male gender 10.824 1.341–87.370 0.025
 Nucleosomes (AU) 15.086 1.785–127.501 0.0127
 CRP (mg/L) 1.004 1.000–1.008 0.045
 Creatinine (μmol/L) 1.010 1.003–1.017 0.005
 Nucleosomes ≥0.57 AU 6.316 1.127–35.402 0.036
 CRP ≥264 mg/L 4.500 1.283–15.778 0.019
 Creatinine ≥110 μmol/L 7.615 2.239–25.900 0.001
Multivariate analysis
 Male gender 8.204 0.968–69.511 0.054
 Creatinine ≥110 μmol/L 6.180 1.742–21.925 0.005
Patients with moderately severe or severe acute pancreatitis (n = 51)
Univariate analysis    
 Age (year) 0.974 0.936–1.014 0.207
 Male gender 9.684 1.110–84.465 0.040
 Nucleosomes (AU) 5.602 0.739–42.474 0.095
 CRP (mg/L) 1.001 0.997–1.005 0.579
 Creatinine (μmol/L) 1.007 1.000–1.013 0.052
 Nucleosomes ≥0.57 AU 3.289 0.575–18.834 0.181
 CRP ≥386 mg/L 2.364 0.201–27.852 0.494
 Creatinine ≥287 μmol/L 6.842 0.738–63.442 0.091
Multivariate analysis    
 Male gender 9.684 1.110–84.465 0.040
Patients with modified marshall score <2 on admission (n = 58)
Univariate analysis    
 Age (year) 0.976 0.936–1.017 0.252
 Male gender 6.724 0.801–56.432 0.079
 Nucleosomes (AU) 33.070 1.216–899.485 0.038
 CRP (mg/L) 1.000 0.993–1.006 0.883
 Creatinine (μmol/L) 1.017 0.998–1.036 0.088
 Nucleosomes ≥0.39 AU 5.467 1.051–28.432 0.043
 CRP ≥ 227 mg/L 1.667 0.271–10.244 0.581
 Creatinine ≥139 μmol/L 7.167 0.598–85.946 0.120
Multivariate analysis    
 Male gender 6.048 0.693–52.799 0.104
 Nucleosomes (AU) 33.070 1.216–899.485 0.038
  1. AU absorbance unit, CRP C-reactive protein, OR odds ratio