Table 4 Performance of circulating nucleosomes, C-reactive protein, and creatinine in predicting severe acute pancreatitis
From: Circulating nucleosomes as predictive markers of severe acute pancreatitis
Cutoff | AUC | Sensitivity | Specificity | +LR | −LR | DOR | |
|---|---|---|---|---|---|---|---|
All patients (n = 74) | |||||||
Nucleosomes | ≥0.57 AU | 0.718 | 0.21 | 0.96 | 5.2 | 0.83 | 6.3 |
(0.578–0.858) | (0.09–0.40) | (0.87–0.99) | (1.1–24.9) | (0.67–1.02) | (1.1–35.4) | ||
CRP | ≥264 mg/L | 0.673 | 0.33 | 0.91 | 3.8 | 0.73 | 5.2 |
(0.583–0.807) | (0.18–0.53) | (0.81–0.96) | (1.4–10.4) | (0.55–0.98) | (1.5–18.1) | ||
Creatinine | ≥110 μmol/L | 0.770 | 0.46 | 0.91 | 5.2 | 0.59 | 8.8 |
(0.654–0.886) | (0.28–0.65) | (0.81–0.96) | (2.0–13.4) | (0.41–0.87) | (2.6–29.8) | ||
Moderately severe and severe AP patients (n = 51) | |||||||
Nucleosomes | ≥0.57 AU | 0.661 | 0.21 | 0.95 | 2.8 | 0.86 | 3.3 |
(0.502–0.821) | (0.09–0.40) | (0.77–0.98) | (0.6–13.2) | (0.68–1.08) | (0.6–18.8) | ||
CRP | ≥386 mg/L | 0.550 | 0.08 | 0.96 | 2.3 | 0.95 | 2.4 |
(0.390–0.710) | (0.02–0.26) | (0.82–0.99) | (0.2–23.3) | (0.83–1.10) | (0.2–27.9) | ||
Creatinine | ≥287 μmol/L | 0.717 | 0.21 | 0.96 | 5.6 | 0.82 | 6.8 |
(0.576–0.858) | (0.09–0.41) | (0.82–0.99) | (0.71–44.8) | (0.66–1.02) | (0.7–63.4) | ||
Patients with modified marshall score <2 on admission (n = 58) | |||||||
Nucleosomes | ≥0.39 AU | 0.648 | 0.29 | 0.93 | 4.2 | 0.77 | 5.5 |
(0.443–0.852) | (0.12–0.55) | (0.82–0.98) | (1.1–16.5) | (0.55–1.08) | (1.1–28.4) | ||
CRP | ≥227 mg/L | 0.539 | 0.14 | 0.92 | 1.8 | 0.93 | 2.0 |
(0.362–0.716) | (0.04–0.40) | (0.82–0.97) | (0.37–8.9) | (0.74–1.17) | (0.3–12.0) | ||
Creatinine | ≥139 μmol/L | 0.670 | 0.14 | 0.98 | 7.3 | 0.87 | 8.3 |
(0.512–0.829) | (0.04–0.40) | (0.90–1.0) | (0.7–74.6) | (0.70–1.09) | (0.7–99.7) | ||