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Table 4 Performance of circulating nucleosomes, C-reactive protein, and creatinine in predicting severe acute pancreatitis

From: Circulating nucleosomes as predictive markers of severe acute pancreatitis

  Cutoff AUC Sensitivity Specificity +LR −LR DOR
All patients (n = 74)
Nucleosomes ≥0.57 AU 0.718 0.21 0.96 5.2 0.83 6.3
   (0.578–0.858) (0.09–0.40) (0.87–0.99) (1.1–24.9) (0.67–1.02) (1.1–35.4)
CRP ≥264 mg/L 0.673 0.33 0.91 3.8 0.73 5.2
   (0.583–0.807) (0.18–0.53) (0.81–0.96) (1.4–10.4) (0.55–0.98) (1.5–18.1)
Creatinine ≥110 μmol/L 0.770 0.46 0.91 5.2 0.59 8.8
   (0.654–0.886) (0.28–0.65) (0.81–0.96) (2.0–13.4) (0.41–0.87) (2.6–29.8)
Moderately severe and severe AP patients (n = 51)
Nucleosomes ≥0.57 AU 0.661 0.21 0.95 2.8 0.86 3.3
   (0.502–0.821) (0.09–0.40) (0.77–0.98) (0.6–13.2) (0.68–1.08) (0.6–18.8)
CRP ≥386 mg/L 0.550 0.08 0.96 2.3 0.95 2.4
   (0.390–0.710) (0.02–0.26) (0.82–0.99) (0.2–23.3) (0.83–1.10) (0.2–27.9)
Creatinine ≥287 μmol/L 0.717 0.21 0.96 5.6 0.82 6.8
   (0.576–0.858) (0.09–0.41) (0.82–0.99) (0.71–44.8) (0.66–1.02) (0.7–63.4)
Patients with modified marshall score <2 on admission (n = 58)
Nucleosomes ≥0.39 AU 0.648 0.29 0.93 4.2 0.77 5.5
   (0.443–0.852) (0.12–0.55) (0.82–0.98) (1.1–16.5) (0.55–1.08) (1.1–28.4)
CRP ≥227 mg/L 0.539 0.14 0.92 1.8 0.93 2.0
   (0.362–0.716) (0.04–0.40) (0.82–0.97) (0.37–8.9) (0.74–1.17) (0.3–12.0)
Creatinine ≥139 μmol/L 0.670 0.14 0.98 7.3 0.87 8.3
   (0.512–0.829) (0.04–0.40) (0.90–1.0) (0.7–74.6) (0.70–1.09) (0.7–99.7)
  1. 95 % confidence intervals are given in parentheses
  2. AU absorbance unit, AUC area under the curve, CRP C-reactive protein, DOR diagnostic odds ratio, LR likelihood ratio