|
Demographic data
| | | |
|
Age (years), mean (SD)
|
55.5 (15.9)
|
53 (16.4)
|
65 (9.8)*
|
|
Male, n (%)
|
27 (67.5)
|
21 (65.6)
|
6 (75.0)
|
|
Severity of illness
| | | |
|
APACHE II score at day 1, median (IQR 25–75)
|
17 (12–21)
|
16 (12–20)
|
22 (18–34)**
|
|
SOFA score at day 1, median (IQR 25–75)
|
4 (3–5)
|
4 (3–5)
|
4 (3–8)
|
|
Major ATS criteria, median (IQR 25–75)
|
28 (70)
|
20 (62.5)
|
8 (100)**
|
|
Invasive mechanical ventilation, n (%)
|
21 (52.5)
|
13 (40.6)
|
8 (100)***
|
|
Severe sepsis, n (%)
|
18 (44.5)
|
17 (53.1)
|
1 (12.5)
|
|
Septic shock, n (%)
|
22 (55.5)
|
15 (46.9)
|
7 (87.5)*
|
|
Mean comorbidities, n (%)
| | | |
|
Tobacco use
|
3 (8.6)
|
3 (10.7)
|
0
|
|
Chronic obstructive pulmonary disease
|
12 (33.3)
|
10 (34.3)
|
2 (28.6)
|
|
Cardiac disease
|
8 (20)
|
6 (18.7)
|
2 (28.6)
|
|
Diabetes mellitus
|
7 (20)
|
5 (17.9)
|
2 (28.6)
|
|
Severe liver disease
|
1 (2.9)
|
0
|
1 (14.3)
|
|
Hemodynamic data, median (IQR 25–75)
| | | |
|
Heart rate, b/min
|
105 (86–114)
|
105 (87–114)
|
105 (85–113)
|
|
Heart rate at 24 h
|
90 (77–100)
|
92 (79–103)
|
85 (70–99)
|
|
Mean arterial pressure, mmHg
|
79 (71–94)
|
78 (72–98)
|
80 (69–88)
|
|
Mean arterial pressure at 24 h
|
79 (70–93)
|
76 (70–96)
|
79 (71–90)
|
|
Central venous pressure, mmHg
|
11 (9–15)
|
11 (8–15)
|
11 (10–14)
|
|
Central venous pressure at 24 h
|
13 (13–16)
|
11 (7–16)
|
14 (12–15)
|
|
Mixed venous oxygen saturation, %a
|
76 (70–79)
|
76 (69–79)
|
74 (74)
|
|
Mixed venous oxygen saturation at 24 ha
|
70 (68–83)
|
70 (68–80)
|
80 (70–91)
|
|
Biochemical data, mean (SD)
| | | |
|
Baseline serum lactate, mM/L
|
3.0 (3.1)
|
2.5 (1.6)
|
4.8 (6.1)
|
|
Serum lactate at 24 h
|
2.0 (2.2)
|
1.4 (0.6)
|
3.9 (4.0)
|
|
Baseline base deficit
|
−3.5 (5.2)
|
−3.6 (5.4)
|
−2.7 (4.3)
|
|
Base deficit at 24 h
|
−2.3 (4.1)
|
−1.9 (4.1)
|
−3.4 (4.2)
|
|
Baseline haemoglobin levels, mg %
|
11.9 (1.8)
|
12.1 (1.9)
|
11.2 (1.1)
|
|
Haemoglobin levels at 24 h
|
10.6 (1.7)
|
10.6 (1.9)
|
10.4 (1.1)
|
|
Baseline serum glucose, mg %
|
166 (74.7)
|
158 (75.3)
|
197 (66.8)
|
|
Serum glucose at 24 h
|
152 (75.6)
|
144 (79.4)
|
177 (58.7)
|
|
Baseline arterial pH
|
7.34 (0.1)
|
7.40 (0.1)
|
7.34 (0.3)
|
|
Arterial pH at 24 h
|
7.36 (0.07)
|
7.30 (0.07)
|
7.32 (0.1)
|
|
Baseline serum creatinine, mg %
|
1.40 (0.9)
|
1.38 (1.03)
|
1.41 (0.8)
|
|
Serum creatinine at 24 h
|
1.1 (0.59)
|
0.9 (0.4)
|
1.5 (0.9)
|
|
rSO2 brachioradialsis
| | | |
|
Baseline rSO2, mean (SD)
|
62.9 (10.7)
|
68 (61–72)
|
46 (43–57)***
|
|
rSO2 at 24 h, mean (SD)
|
65.4 (12.3)
|
69 (60–76)
|
52 (41–57)***
|
|
Baseline rSO2 < 60, n (%)
|
14 (35)
|
7 (21.9)
|
7 (87.5)***
|
|
rSO2 < 60 at 24 h, n (%)
|
6 (15.8)
|
4 (12.5)
|
7 (87.5)***
|
|
Therapy, mean (SD)
| | | |
|
Norepinephrine at baseline μg/kg/min
|
0.35 (0.26)
|
0.40 (0.14)
|
0.29 (0.36)
|
|
Norepinephrine at 24 h, μg/kg/min
|
0.35 (0.29)
|
0.22 (0.28)
|
0.52 (0.23)*
|
|
Fluid balance at 24 h, mL
|
1650 (1350)
|
1470 (800)
|
2300 (2500)
|
|
ICU length of stay
| | | |
|
Median IQR 25–75 %
|
18 (11–30)
|
18 (11–31)
|
24 (8–30)
|
