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Table 1 Baseline and peak CBG, cFC, SaC and STC levels on D1 and D7

From: Comparison of total, salivary and calculated free cortisol levels in patients with severe sepsis

Day of the study

D1

D7

Healthy

p1

p2

p3

p4

p5

p6

p7

p8

All SS patients

SS with high STC

SS with low STC

All SS patients

SS with high STC

SS with low STC

         

n

30

19

11

14

4

10

16

        

STC (μg/dL)

Baseline

13.7 (3.1–53.2)

18.7 (10.4–53.2)

8.2 (3.1–9.4)

7.6 (0.4–13.9)

12.4 (12.0–13.9)

6.5 (0.4–9.6)

14.3 (4.3–20)

0.13

< 0.01

< 0.01

< 0.01

< 0.01

0.01

0.67

0.03

Peak

20.3 (7.4–52.0)

31.0 (14.1–52.0)

11.0 (7.4–20.6)

12.7 (4.0–25.0)

18.9 (8.3–25.0)

12.4 (3.9–21.4)

27 (15.2–41.4)

0.64

<0.01

0.27

<0.01

<0.01

0.24

0.02

<0.01

SaC (μg/dL)

Baseline

1.9 (0.2–9.0)

2.3 (0.2–9.0)

0.9 (0.2–2.9)

0.7 (0.3–4.6)

1.1 (0.8–4.6)

0.6 (0.3–3.0)

0.4 (0.1–1.4)

<0.01

0.15

<0.01

0.09

0.04

0.07

0.06

0.72

Peak

2.2 (0.5–17.8)

3.4 (0.5–17.8)

1.9 (0.6–4.2)

1.7 (0.2–4.0)

2.6 (1.3–2.9)

1.5 (0.2–4.0)

1.1 (0.4–2.5)

<0.01

0.02

<0.01

0.11

0.37

0.39

0.01

0.14

cFC (μg/dL)

Baseline

0.5 (0.1–1.9)

0.7 (0.4–1.9)

0.3 (0.1–0.3)

0.3 (0.1–0.5)

0.4 (0.4–0.5)

0.2 (0.1–0.3)

0.7 (0.4–1.9)

0.48

<0.01

<0.01

<0.01

<0.01

0.01

0.65

<0.01

Peak

0.71 (0.3–1.9)

1.1 (0.5–1.9)

0.4 (0.3–0.7)

0.4 (0.1–0.9)

0.7 (0.3–0.9)

0.4 (0.1–0.7)

1.8 (1.0–6.6)

<0.01

<0.01

<0.01

<0.01

<0.01

0.24

0.89

0.12

CBG (μg/dL)

Baseline

0.3 (0.1–0.6)

0.3 (0.1–0.6)

0.2 (0.1–0.4)

0.3 (0.2–0.5)

0.4 (0.3–0.4)

0.3 (0.2–0.5)

0.5 (0.3–0.8)

< 0.01

0.12

< 0.01

< 0.01

< 0.01

0.94

< 0.01

< 0.01

Peak

0.3 (0.1–0.5)

0.3 (0.1–0.5)

0.3 (0.1–0.5)

0.4 (0.1–0.5)

0.3 (0.2–0.4)

0.4 (0.1–0.5)

0.6 (0.4–0.9)

< 0.01

0.6

< 0.01

< 0.01

< 0.01

0.35

< 0.01

< 0.01

  1. Abbreviations: D1 first day of severe sepsis, n number of the subjects, STC serum total cortisol, SaC salivary cortisol, cFC calculated free cortisol, CBG cortisol binding globulin, p1 belongs to comparison between hormon levels of the patients with severe sepsis on D1 and healthy control, p2 belongs to comparison between patients who have basal STC ≥ or <10 μg/dL on D1, p3 belongs to comparison between patients with severe sepsis who have baseline STC ≥10 μg/dL on D1 and healthy control, p4 belongs to comparison between patients with severe sepsis who have baseline STC <10 μg/dL on D1 and healthy control, p5 belongs to comparison between hormone levels of the patients with severe sepsis on D7 and healthy control, p6 belongs to comparison between patients who have baseline STC ≥ or <10 μg/dL on D7, p7 belongs to comparison between patients with sepsis who have baseline STC ≥10 μg/dL on D7 and healthy control, p8 belongs to comparison between patients with sepsis who have baseline STC <10 μg/dL on D7 and healthy control
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Journal of Intensive Care

ISSN: 2052-0492