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Table 1 Baseline and peak CBG, cFC, SaC and STC levels on D1 and D7

From: Comparison of total, salivary and calculated free cortisol levels in patients with severe sepsis

Day of the study D1 D7 Healthy p1 p2 p3 p4 p5 p6 p7 p8
All SS patients SS with high STC SS with low STC All SS patients SS with high STC SS with low STC          
n 30 19 11 14 4 10 16         
STC (μg/dL) Baseline 13.7 (3.1–53.2) 18.7 (10.4–53.2) 8.2 (3.1–9.4) 7.6 (0.4–13.9) 12.4 (12.0–13.9) 6.5 (0.4–9.6) 14.3 (4.3–20) 0.13 < 0.01 < 0.01 < 0.01 < 0.01 0.01 0.67 0.03
Peak 20.3 (7.4–52.0) 31.0 (14.1–52.0) 11.0 (7.4–20.6) 12.7 (4.0–25.0) 18.9 (8.3–25.0) 12.4 (3.9–21.4) 27 (15.2–41.4) 0.64 <0.01 0.27 <0.01 <0.01 0.24 0.02 <0.01
SaC (μg/dL) Baseline 1.9 (0.2–9.0) 2.3 (0.2–9.0) 0.9 (0.2–2.9) 0.7 (0.3–4.6) 1.1 (0.8–4.6) 0.6 (0.3–3.0) 0.4 (0.1–1.4) <0.01 0.15 <0.01 0.09 0.04 0.07 0.06 0.72
Peak 2.2 (0.5–17.8) 3.4 (0.5–17.8) 1.9 (0.6–4.2) 1.7 (0.2–4.0) 2.6 (1.3–2.9) 1.5 (0.2–4.0) 1.1 (0.4–2.5) <0.01 0.02 <0.01 0.11 0.37 0.39 0.01 0.14
cFC (μg/dL) Baseline 0.5 (0.1–1.9) 0.7 (0.4–1.9) 0.3 (0.1–0.3) 0.3 (0.1–0.5) 0.4 (0.4–0.5) 0.2 (0.1–0.3) 0.7 (0.4–1.9) 0.48 <0.01 <0.01 <0.01 <0.01 0.01 0.65 <0.01
Peak 0.71 (0.3–1.9) 1.1 (0.5–1.9) 0.4 (0.3–0.7) 0.4 (0.1–0.9) 0.7 (0.3–0.9) 0.4 (0.1–0.7) 1.8 (1.0–6.6) <0.01 <0.01 <0.01 <0.01 <0.01 0.24 0.89 0.12
CBG (μg/dL) Baseline 0.3 (0.1–0.6) 0.3 (0.1–0.6) 0.2 (0.1–0.4) 0.3 (0.2–0.5) 0.4 (0.3–0.4) 0.3 (0.2–0.5) 0.5 (0.3–0.8) < 0.01 0.12 < 0.01 < 0.01 < 0.01 0.94 < 0.01 < 0.01
Peak 0.3 (0.1–0.5) 0.3 (0.1–0.5) 0.3 (0.1–0.5) 0.4 (0.1–0.5) 0.3 (0.2–0.4) 0.4 (0.1–0.5) 0.6 (0.4–0.9) < 0.01 0.6 < 0.01 < 0.01 < 0.01 0.35 < 0.01 < 0.01
  1. Abbreviations: D1 first day of severe sepsis, n number of the subjects, STC serum total cortisol, SaC salivary cortisol, cFC calculated free cortisol, CBG cortisol binding globulin, p1 belongs to comparison between hormon levels of the patients with severe sepsis on D1 and healthy control, p2 belongs to comparison between patients who have basal STC ≥ or <10 μg/dL on D1, p3 belongs to comparison between patients with severe sepsis who have baseline STC ≥10 μg/dL on D1 and healthy control, p4 belongs to comparison between patients with severe sepsis who have baseline STC <10 μg/dL on D1 and healthy control, p5 belongs to comparison between hormone levels of the patients with severe sepsis on D7 and healthy control, p6 belongs to comparison between patients who have baseline STC ≥ or <10 μg/dL on D7, p7 belongs to comparison between patients with sepsis who have baseline STC ≥10 μg/dL on D7 and healthy control, p8 belongs to comparison between patients with sepsis who have baseline STC <10 μg/dL on D7 and healthy control