T-5224, a selective inhibitor of c-Fos/activator protein-1, improves survival by inhibiting serum high mobility group box-1 in lethal lipopolysaccharide-induced acute kidney injury model

Table 1 Change in serum TNF-α, HMGB-1, IL-10, and BUN and creatinine concentrations

	Serum TNF-α (pg/ml, n = 7)	Serum HMGB-1 (ng/ml, n = 7)	Serum IL-10 (pg/ml, n = 7)	Serum BUN	Serum creatinine
	Serum TNF-α (pg/ml, n = 7)	Serum HMGB-1 (ng/ml, n = 7)	Serum IL-10 (pg/ml, n = 7)	(mg/dl, n = 7)
Control	39.5 (36.0–47.0)	19.8 (19.0–23.4)	59.5 (48.8–62.9)	29.6 (27.2–30.7)	0.11 (0.10–0.12)
LPS	2738.0 (2429.7–3377.2)**	169.8 (166.7–224.5)**	1361.0 (1256.3–1603.9)**	98.8 (95.3–102.8)**	0.35 (0.34–0.38)**
LPS + T-5224	1533.0 (1453.9–1602.6)**^,##	132.8 (119.1–140.6)**^,##	3165.0 (2897.8–3400.8)**^,##	70.5 (68.4–76.8)**^,##	0.28 (0.22–0.29)**^,##
T-5224	32.0 (30.0–34.0)	19.4 (17.9–21.1)	64.9 (55.6–70.1)	28.0 (24.0–28.7)	0.10 (0.09–0.11)

Control: mice received PVP solution orally immediately after saline injection. LPS: mice received PVP solution orally immediately after LPS (10 mg/kg) injection. LPS + T-5224: mice received T-5224 (300 mg/kg) immediately after LPS injection. T-5224: mice received T-5224 (300 mg/kg) after saline injection. Data are represented as medians with interquartile ranges
TNF-α tumor necrosis factor-alpha, HMGB-1 high mobility group box-1, IL-10 interleukin-10, BUN blood urea nitrogen
**P < 0.01 compared with control group. ^## P < 0.01 compared with LPS group

ISSN: 2052-0492