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Table 1 Change in serum TNF-α, HMGB-1, IL-10, and BUN and creatinine concentrations

From: T-5224, a selective inhibitor of c-Fos/activator protein-1, improves survival by inhibiting serum high mobility group box-1 in lethal lipopolysaccharide-induced acute kidney injury model

  Serum TNF-α
(pg/ml, n = 7)
Serum HMGB-1
(ng/ml, n = 7)
Serum IL-10
(pg/ml, n = 7)
Serum BUN Serum creatinine
(mg/dl, n = 7)
Control 39.5 (36.0–47.0) 19.8 (19.0–23.4) 59.5 (48.8–62.9) 29.6 (27.2–30.7) 0.11 (0.10–0.12)
LPS 2738.0 (2429.7–3377.2)** 169.8 (166.7–224.5)** 1361.0 (1256.3–1603.9)** 98.8 (95.3–102.8)** 0.35 (0.34–0.38)**
LPS + T-5224 1533.0 (1453.9–1602.6)**,## 132.8 (119.1–140.6)**,## 3165.0 (2897.8–3400.8)**,## 70.5 (68.4–76.8)**,## 0.28 (0.22–0.29)**,##
T-5224 32.0 (30.0–34.0) 19.4 (17.9–21.1) 64.9 (55.6–70.1) 28.0 (24.0–28.7) 0.10 (0.09–0.11)
  1. Control: mice received PVP solution orally immediately after saline injection. LPS: mice received PVP solution orally immediately after LPS (10 mg/kg) injection. LPS + T-5224: mice received T-5224 (300 mg/kg) immediately after LPS injection. T-5224: mice received T-5224 (300 mg/kg) after saline injection. Data are represented as medians with interquartile ranges
  2. TNF-α tumor necrosis factor-alpha, HMGB-1 high mobility group box-1, IL-10 interleukin-10, BUN blood urea nitrogen
  3. **P < 0.01 compared with control group. ## P < 0.01 compared with LPS group