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Fig. 2 | Journal of Intensive Care

Fig. 2

From: T-5224, a selective inhibitor of c-Fos/activator protein-1, improves survival by inhibiting serum high mobility group box-1 in lethal lipopolysaccharide-induced acute kidney injury model

Fig. 2

Effects of T-5224 on renal histopathology. T-5224 attenuated mild morphological damage, including necrotic degeneration with pyknotic nuclei. The sections shown were harvested 24 h after LPS injection and stained with H & E. a Control: mice received PVP solution orally immediately after i.p. saline injection. b LPS: LPS mice received PVP solution orally immediately after i.p. LPS (10 mg/kg body weight) injection. LPS caused necrotic degeneration with pyknotic nucleus (arrow head). c LPS + T-5224: LPS + T-5224 mice received T-5224 (300 mg/kg) immediately after LPS injection. There was less necrotic degeneration following T-5224 treatment. d T-5224: T-5224 mice received T-5224 (300 mg/kg) after i.p. saline injection. Scale bars = 100 μm. n = 5 for each group

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