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Table 3 Procalcitonin diagnostic levels for sepsis in prospective studies in ICU populations

From: Procalcitonin-guided antibiotic therapy for septic patients in the surgical intensive care unit

Name Year Number Ref PCT <0.5 0.6 to <1.0 1.1 to <1.5 1.6 to 2.0 Sensitivity (%) Specificity (%)
Al-Nawas 1996 337 [32] 0.5     60 79
Bossink 1999 200 [33] 0.5     65 58
Sudhir 2011 100 [34] 0.5     94
Ugarte 1999 205 [35]   0.6    68 61
Muller 2000 101 [36]   1.0    89 94
Aouifi 2000 97 [37]   1.0    85 95
Ruokonen 2002 208 [38]   0.8    68 48
G-B 2002 119 [39]   1.0    95 65
Whang 1998 29 [40]    1.1   67 80
Oberhoffer 2000 242 [41]    1.4   84 83
Wanner 2000 405 [42]    1.5   76a 77
Harbarth 2001 78 [9]    1.1   97 78
Tugrul 2002 85 [43]    1.3   73 83
Hensler 2003 137 [44]    1.5   42a 73
Castelli 2004 150 [18]    1.1   79 85
Mokart 2005 50 [45]    1.1   81 72
Brunkhorst 2000 185 [46]     2.0 96 86
Suprin 2000 101 [47]     2.0 65 70
Meisner 2002 208 [48]     2.0 87 78
DeTalance 2003 108 [49]     2.0 91 89
Luzzani 2003 70 [50]     2.0 76 84
Du 2003 51 [51]     1.6 80 74
Geppert 2003 55 [52]     2.0 87 75
Endo 2008 82 [53]     2.0 95 78
Meynaar 2011 76 [54]     2.0 97 80
  1. aThese studies included trauma patients, PCT is known to rise after trauma unrelated to sepsis
  2. ref reference