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Table 1 Results of prospective randomized trials

From: Procalcitonin-guided antibiotic therapy for septic patients in the surgical intensive care unit

Country Author Ref Trial name Year Number Population PCT E PCT C Number of fewer days of antibiotic use
Use in respiratory infections
Switzerland Christ-Crain [20] None 2006 302 CAP 0.57 0.44 Yes, 7 days
Switzerland Briel [23] None 2008 458 resp infect 0.8 0.8 Yes, 1 day
Swiss/USA Stolz [25] None 2009 101 VAP 0.6 0.7 Yes, 5 days
Switzerland Schuetz [26] ProHosp 2009 1359 resp infect 0.24 0.24 Yes, 3 days
Use in sepsis
Switzerland Nobre [21] None 2008 79 Sepsis 8.4 5.9 Yes, 3.5 days
Germany Schroeder [22] None 2008 27 Severe sepsis 7.0 6.0 Yes, 1.7 days
Sepsis in the ICU setting
Germany Hochreiter [24] None 2009 110 SICU 4.5 4.8 Yes, 2 days
France Bouadma [27] PRORATA 2010 621 ICU 12.0 12.0 Yes, 3 days
Netherlands De Jong [28] SAPS 2013 1816 ICU Results pending
Australia Shehabi [30] ProGuard 2014 400 ICU 5.7 8.8 No, 2 days not statistically significant
  1. Ref reference number, n number of patients enrolled in the study, CAP community-acquired pneumonia, resp infect respiratory infection, SICU surgical intensive care unit, VAP ventilator-associated pneumonia, ICU intensive care unit, PCT E initial procalcitonin level in the experimental group (ng/mL), PCT C initial procalcitonin level in the control group (ng/mL)