Procalcitonin-guided antibiotic therapy for septic patients in the surgical intensive care unit

Table 1 Results of prospective randomized trials

Country	Author	Ref	Trial name	Year	Number	Population	PCT E	PCT C	Number of fewer days of antibiotic use
Use in respiratory infections
Switzerland	Christ-Crain	[20]	None	2006	302	CAP	0.57	0.44	Yes, 7 days
Switzerland	Briel	[23]	None	2008	458	resp infect	0.8	0.8	Yes, 1 day
Swiss/USA	Stolz	[25]	None	2009	101	VAP	0.6	0.7	Yes, 5 days
Switzerland	Schuetz	[26]	ProHosp	2009	1359	resp infect	0.24	0.24	Yes, 3 days
Use in sepsis
Switzerland	Nobre	[21]	None	2008	79	Sepsis	8.4	5.9	Yes, 3.5 days
Germany	Schroeder	[22]	None	2008	27	Severe sepsis	7.0	6.0	Yes, 1.7 days
Sepsis in the ICU setting
Germany	Hochreiter	[24]	None	2009	110	SICU	4.5	4.8	Yes, 2 days
France	Bouadma	[27]	PRORATA	2010	621	ICU	12.0	12.0	Yes, 3 days
Netherlands	De Jong	[28]	SAPS	2013	1816	ICU	–	–	Results pending
Australia	Shehabi	[30]	ProGuard	2014	400	ICU	5.7	8.8	No, 2 days not statistically significant

Ref reference number, n number of patients enrolled in the study, CAP community-acquired pneumonia, resp infect respiratory infection, SICU surgical intensive care unit, VAP ventilator-associated pneumonia, ICU intensive care unit, PCT E initial procalcitonin level in the experimental group (ng/mL), PCT C initial procalcitonin level in the control group (ng/mL)

ISSN: 2052-0492