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Table 1 Summary of six randomized control trials to compare the outcome of treatment between larger vs. smaller tidal volumes of mechanical ventilation in the patients with ARDS [1015]

From: Mechanical ventilation of acute respiratory distress syndrome

  Author (journal)
  Amato (NEJM 1998) [10] ARDSNet (NEJM 2000) [11] Brochard (AJRCCM 1998) [12] Brower (CCM 1999) [13] Stewart (NEJM 1998) [14] Villar (NEJM 2006) [15]
Control n 24 429 58 26 60 45
V T (ml/kg) 763 (26)a 11.8 (0.8) 10.3 (1.7) 10.2 (0.1) 10.7 (1.4) 10.2 (1.2)
PEEP (cm H2O) 6.9 (0.8) 8.6 (3.6) 10.7 (2.3) 8.8 (0.8) 7.2 (3.3) 9.0 (2.7)
Plateau P. (cm H2O) 34.4 (1.9) 33 (9) 31.7 (6.6) 30.6 (0.8) 26.8 (6.7) 32.6 (6.2)
Mortality (%) 71.0 39.8 37.9 50.0 47.0 53.3
Pneumonia (%) 63.0 36.0   40.0 48.3 29.0
Sepsis (%) 79.0 26.0   20.0 35.0 26.7
Protective n 29 432 58 26 60 50
V T (ml/kg) 362 (11)a 6.2 (0.9) 7.1 (1.3) 7.3 (0.1) 7.0 (0.7) 7.3 (0.9)
PEEP (cm H2O) 16.3 (0.7) 9.4 (3.6) 10.7 (2.9) 9.8 (0.8) 8.6 (3.0) 14.1 (2.8)
Plateau P. (cm H2O) 31.8 (1.4) 25 (7) 25.7 (5.0) 24.9 (0.8) 22.3 (5.4) 30.6 (6.0)
Mortality (%) 38.0* 31.0* 46.6 46.0 50.0 32.0*
Pneumonia (%) 52.0 33.0   70.0 35.0 32.0
Sepsis (%) 86.0 27.0   20.0 43.3 28.0
  1. Numbers in parentheses are standard deviations
  2. NEJM New England Journal of Medicine, AJRCCM American Journal of Respiratory and Critical Care Medicine, CCM Critical Care Medicine
  3. *p <0.05, compared with control
  4. aml