Table 1 Summary of six randomized control trials to compare the outcome of treatment between larger vs. smaller tidal volumes of mechanical ventilation in the patients with ARDS [10–15]
From: Mechanical ventilation of acute respiratory distress syndrome
| Â | Author (journal) | ||||||
|---|---|---|---|---|---|---|---|
| Â | Amato (NEJM 1998) [10] | ARDSNet (NEJM 2000) [11] | Brochard (AJRCCM 1998) [12] | Brower (CCM 1999) [13] | Stewart (NEJM 1998) [14] | Villar (NEJM 2006) [15] | |
Control | n | 24 | 429 | 58 | 26 | 60 | 45 |
V T (ml/kg) | 763 (26)a | 11.8 (0.8) | 10.3 (1.7) | 10.2 (0.1) | 10.7 (1.4) | 10.2 (1.2) | |
PEEP (cm H2O) | 6.9 (0.8) | 8.6 (3.6) | 10.7 (2.3) | 8.8 (0.8) | 7.2 (3.3) | 9.0 (2.7) | |
Plateau P. (cm H2O) | 34.4 (1.9) | 33 (9) | 31.7 (6.6) | 30.6 (0.8) | 26.8 (6.7) | 32.6 (6.2) | |
Mortality (%) | 71.0 | 39.8 | 37.9 | 50.0 | 47.0 | 53.3 | |
Pneumonia (%) | 63.0 | 36.0 | Â | 40.0 | 48.3 | 29.0 | |
Sepsis (%) | 79.0 | 26.0 | Â | 20.0 | 35.0 | 26.7 | |
Protective | n | 29 | 432 | 58 | 26 | 60 | 50 |
V T (ml/kg) | 362 (11)a | 6.2 (0.9) | 7.1 (1.3) | 7.3 (0.1) | 7.0 (0.7) | 7.3 (0.9) | |
PEEP (cm H2O) | 16.3 (0.7) | 9.4 (3.6) | 10.7 (2.9) | 9.8 (0.8) | 8.6 (3.0) | 14.1 (2.8) | |
Plateau P. (cm H2O) | 31.8 (1.4) | 25 (7) | 25.7 (5.0) | 24.9 (0.8) | 22.3 (5.4) | 30.6 (6.0) | |
Mortality (%) | 38.0* | 31.0* | 46.6 | 46.0 | 50.0 | 32.0* | |
Pneumonia (%) | 52.0 | 33.0 | Â | 70.0 | 35.0 | 32.0 | |
Sepsis (%) | 86.0 | 27.0 | Â | 20.0 | 43.3 | 28.0 | |