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Table 2 Pharmacokinetic parameters of levofloxacin in the patients receiving continuous hemodiafiltration

From: Pharmacokinetics and the optimal regimen for levofloxacin in critically ill patients receiving continuous hemodiafiltration

Patient

CL total (l/h)

t 1/2 (h)

C max (mcg/ml)

AUC [(mg/l) h]

1

4.62

13.1

5.7

108.3

2

12.3

14.4

3.0

40.8

3

6.64

28.9

4.7

75.3

4

7.01

11.4

4.4

71.3

Mean ± SE

7.63 + 1.6

16.9 + 4.0

4.5 + 0.6

73.9 + 13.8

  1. CL total total clearance, t1/2 a half-life, C max maximum concentration, AUC area under the concentration-time curve, SE standard error.