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Table 2 Pharmacokinetic parameters of levofloxacin in the patients receiving continuous hemodiafiltration

From: Pharmacokinetics and the optimal regimen for levofloxacin in critically ill patients receiving continuous hemodiafiltration

Patient CL total (l/h) t 1/2 (h) C max (mcg/ml) AUC [(mg/l) h]
1 4.62 13.1 5.7 108.3
2 12.3 14.4 3.0 40.8
3 6.64 28.9 4.7 75.3
4 7.01 11.4 4.4 71.3
Mean ± SE 7.63 + 1.6 16.9 + 4.0 4.5 + 0.6 73.9 + 13.8
  1. CL total total clearance, t1/2 a half-life, C max maximum concentration, AUC area under the concentration-time curve, SE standard error.