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Table 6 Efficacy of treatment for new-onset atrial fibrillation

From: Epidemiology, prevention, and treatment of new-onset atrial fibrillation in critically ill: a systematic review

Author, year [ref] Study design Severity score Observation period Intervention Conversion rate Hospital mortality (%)
Balser JR, 1998 [58] Randomized controlled APACHE III 59 Within 2 h Esmolol 59.1% [20/34] p = 0.067 31
65 Diltiazem 27.3% [6/22] 38
Seguin P, 2006 [51] Prospective observational SAPS II 47 10 ± 10 h DC 100% [3/3] NA 31.2
Amiodarone 100% [4/4]
Digoxin 100% [1/1]
No intervention 100% [4/4]
Sleeswijk ME, 2008 [59] Prospective observational APACHE II 19 Within 24 h MgSO4-amiodarone step-up scheme 93.1% [27/29] NA 37.9
Meierhenrich R, 2010 [53] Prospective observational SAPS II 31a NA DC (17/49) 85.7% [42/49]c NA 48ad
34b Amiodarone (36/49) 23bd
Digitalis (31/49)
β-Blockers (25/49)
Kanji S, 2012 [55] Retrospective observational APACHE II 22.6 Within 24 h DCe 26.9% [7/26] NA 32
Amiodaronef 87.4% [90/103]
Sotalol 100% [2/2]
Rate control 75% [21/28]
  1. AF atrial fibrillation, DC direct current cardioversion, LOS length of stay, MgSO 4 magnesium sulfate, NA not available.
  2. aNew-onset AF, no septic shock.
  3. bNew-onset AF and septic shock.
  4. cThe efficacy of each intervention was unknown because of a combination of these interventions.
  5. dSixty-day mortality.
  6. eEighteen of 26 had received amiodarone.
  7. fAmiodarone alone.