Bender JS, 1996 [49]
|
Prospective observational
|
206
|
Surgical ICU
|
Etiology
|
Seguin P, 2004 [50]
|
Prospective observational
|
453
|
Surgical ICU
|
Etiology/outcome
|
Seguin P, 2006 [51]
|
Prospective observational
|
293
|
Surgical ICU (trauma)
|
Etiology/outcome treatment
|
Arora S, 2007 [52]
|
Prospective observational
|
61
|
Mixed ICU
|
Etiology/outcome
|
Christian SA, 2008 [26]
|
Retrospective observational
|
272
|
Mixed ICU (sepsis)
|
Etiology/outcome
|
Meierhenrich R, 2010 [53]
|
Prospective observational
|
629 (50 septic shock)
|
Surgical ICU
|
Etiology/outcome treatment
|
Walkey AJ, 2011 [54]
|
Retrospective population-based cohort
|
49,082
|
Acute care hospitals (severe sepsis)
|
Etiology/outcome
|
Kanji S, 2012 [55]
|
Retrospective observational
|
3,081
|
Three mixed ICUs
|
Etiology treatment
|
Tongyaoo S, 2013 [56]
|
Prospective observational
|
247
|
Medical ICU
|
Etiology/outcome
|
Makrygiannis SS, 2014 [57]
|
Prospective observational
|
133
|
Mixed ICU
|
Etiology
|
Balser JR, 1998 [60]
|
Randomized controlled
|
64a
|
Surgical ICU
|
Treatment
|
Sleeswijk ME, 2008 [61]
|
Prospective observational
|
29
|
Mixed ICU
|
Treatment
|