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Table 4 Prognostic factors of mortality in patients with VAP caused by A. baumannii , univariable Cox’s proportional hazards regression analysis

From: Prognostic factors associated with mortality of drug-resistant Acinetobacter baumannii ventilator-associated pneumonia

Predictors HR 95% CI P value
Male gender 1.31 0.96–1.79 0.088
Age >60 1.08 0.79–1.48 0.609
Comorbidities    
 Renal diseases 1.24 0.89–1.70 0.193
 Cerebrovascular diseases 0.85 0.59–1.21 0.365
 Cardiovascular diseases 0.95 0.67–1.34 0.790
 COPD 0.90 0.60–1.37 0.638
 DM 1.13 0.76–1.70 0.541
 Immunocompromised hosts 1.68 1.18–2.40 0.004
 Malignancy 2.24 1.54–3.27 <0.001
 Hematologic diseases 1.50 0.92–2.45 0.102
 Hepatic diseases 1.15 0.67–2.00 0.601
Late-onset VAP 1.05 0.64–1.71 0.846
CXR: extents of infiltration    
 Multi-lobes 1.41 0.91–2.19 0.128
Septic shock 6.60 4.54–9.60 <0.001
Severity score    
 SAPS II >45 5.36 3.71–7.73 <0.001
 SOFA >5 8.18 5.20–12.87 <0.001
Admission 7 days before VAP onset 1.18 0.85–1.62 0.309
Pathogens    
Polymicrobial 1.15 0.84–1.56 0.385
P. aeruginosa 1.34 0.95–1.90 0.095
 MRSA 1.45 0.97–2.14 0.065
K. pneumoniae 1.27 0.67–2.41 0.460
 Othersa 0.69 0.36–1.30 0.249
Groups of A. baumannii    
 DS 1   
 MDR 1.75 0.74–4.16 0.119
 XDR 3.38 1.58–7.25 0.002
 PDR 4.42 1.60–12.20 0.004
Empirical antibiotic treatment    
 Combined antibiotics 1.28 0.91–1.78 0.152
 Inappropriate 2.30 1.70–3.13 <0.001
  1. SAPS II Simplified Acute Physiology Score II, SOFA Sequential Organ Failure Assessment, DS drug-sensitive, MDR multidrug-resistant, XDR extensively drug-resistant, PDR pandrug-resistant A. baumannii, MRSA methicillin-resistant Staphylococcus aureus, CXR chest X-ray.
  2. aOthers including E. coli, S. maltophilia, H. influenzae, methicillin-sensitive Staphylococcus aureus, Enterococcus spp., VAP ventilator-associated pneumonia.