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Table 3 Comparison of two different salts of colistin

From: Colistin for lung infection: an update

  Colistimethate sodium Colistin sulfate
Prepared from Colistin (chemically modified) Synthesized non-ribosomally from Bacillus polymyxa subspecies colistinus
Salt Sodium Sulfate
Chemically Polyanion Polycation
Stability Less More
Elimination Renal Non-renal
Half-life ~2 h ~4 h
Anti-microbial activity Non-active prodrug: 32 different products Active
Available for Parenteral use, inhalation use Oral and topical use, inhalation use