Table 3 Comparison of two different salts of colistin
| Â | Colistimethate sodium | Colistin sulfate |
|---|---|---|
Prepared from | Colistin (chemically modified) | Synthesized non-ribosomally from Bacillus polymyxa subspecies colistinus |
Salt | Sodium | Sulfate |
Chemically | Polyanion | Polycation |
Stability | Less | More |
Elimination | Renal | Non-renal |
Half-life | ~2Â h | ~4Â h |
Anti-microbial activity | Non-active prodrug: 32 different products | Active |
Available for | Parenteral use, inhalation use | Oral and topical use, inhalation use |