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Table 1 History of colistin

From: Colistin for lung infection: an update

Year Event
1947 Discovery of polymyxins from bacteria Paenibacillus polymyxa
1949 Colistin (polymyxin E) was first time isolated from Bacillus polymyxa var. colistinus by Koyama Y. and colleagues in Japan
1959 Colistin became available in intravenous formulation (as colistimethate sodium) for clinical uses
1960s–1970s Colistin used for gram-negative infection; later on, uses decline due to its toxicities
1990s–2000s Used mainly for lung infection due to MDR gram-negative pathogens in patients with cystic fibrosis
2000 onwards Currently in use to treat healthcare-associated MDR gram-negative infection