Patient characteristic | Unadjusted groups | IPTW Groups | Matched groups | ||||||
---|---|---|---|---|---|---|---|---|---|
Sivelestat (n  = 87) | Control (n  = 77) | Standardized difference | Sivelestat (n  = 162) | Control (n  = 167) | Standardized difference | Sivelestat (n  = 31) | Control (n  = 31) | Standardized difference | |
Age, year | 66.1 (17.5) | 65.9 (16.2) | 0.01 | 67.7 (16.2) | 69.0 (15.8) | −0.08 | 69.8 (15.6) | 67.3 (15.3) | 0.16 |
Male sex | 57 (65.5) | 50 (64.9) | 0.01 | 104 (64.2) | 114 (68.3) | −0.09 | 21 (67.7) | 19 (61.3) | 0.13 |
Academic hospital | 49 (56.3) | 48 (63.3) | −0.14 | 92 (56.8) | 86 (51.8) | 0.10 | 20 (64.5) | 15 (48.4) | 0.33 |
Hospital volume (cases) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Low (1–10) | 37 (42.5) | 43 (55.8) | −0.27 | 73 (45.1) | 70 (41.9) | 0.06 | 15 (48.4) | 14 (45.2) | 0.06 |
 Medium (11–20) | 19 (21.8) | 18 (23.4) | −0.04 | 32 (19.8) | 34 (20.4) | −0.01 | 8 (25.8) | 5 (16.1) | 0.28 |
 High (≥21) | 31 (35.6) | 16 (20.8) | 0.33 | 57 (35.2) | 63 (37.7) | −0.05 | 8 (25.8) | 12 (38.7) | −0.28 |
Direct lung injury | 54 (62.1) | 44 (57.1) | 0.10 | 94 (58.4) | 104 (62.3) | −0.08 | 19 (61.3) | 21 (67.7) | −0.13 |
APACHE II | 22.2 (7.4) | 23.5 (7.4) | −0.18 | 23.5 (7.3) | 23.3 (7.5) | 0.03 | 23.7 (5.5) | 24.0 (7.6) | −0.05 |
SOFA score | 10.1 (3.3) | 11.2 (3.6) | −0.32 | 10.7 (3.3) | 10.6 (3.7) | 0.03 | 10.8 (3.3) | 10.0 (3.2) | 0.25 |
SIRS score | 2.3 (1.0) | 2.4 (1.2) | −0.09 | 2.4 (1.1) | 2.4 (1.1) | 0.00 | 2.4 (1.2) | 2.5 (1.1) | −0.09 |
MAP, mmHg | 75.5 (18.3) | 77.2 (15.5) | −0.10 | 77.3 (19.1) | 78.8 (17.2) | −0.08 | 75.8 (20.1) | 73.9 (14.3) | 0.11 |
CVP, mmHg | 10.7 (5.4) | 9.3 (5.2) | 0.26 | 9.8 (5.2) | 9.7 (5.1) | 0.02 | 10.5 (4.7) | 9.5 (5.8) | 0.19 |
Fluid balance on Day 0, mL | 2,239 (2,228) | 1,498 (1,640) | 0.38 | 1,915 (1,977) | 1,861 (1,686) | 0.03 | 1,495 (2,267) | 1,673 (2,333) | −0.08 |
PaO2/FiO2 | 148.5 (73.1) | 148.4 (65.6) | 0 | 142.9 (70.2) | 145.6 (63.9) | −0.04 | 141.7 (71.1) | 128.5 (60.2) | 0.20 |
PEEP, cm/H2O | 8.4 (4.9) | 8.3 (4.1) | 0.02 | 8.2 (4.6) | 8.1 (3.8) | 0.02 | 8.1 (5.0) | 8.8 (4.6) | −0.15 |
Cardiac index, L/m2 | 3.5 (1.4) | 3.5 (1.2) | 0 | 3.4 (1.4) | 3.4 (1.1) | 0.00 | 3.7 (1.5) | 3.2 (1.0) | 0.39 |
GEDI, mL/m2 | 836.9 (236.4) | 784.2 (158.0) | 0.26 | 809.9 (208.4) | 805.2 (149.3) | 0.03 | 805.9 (167.5) | 761.9 (150.1) | 0.28 |
EVLWi, mL/kg | 20.0 (7.1) | 17.2 (6.4) | 0.41 | 19.1 (6.4) | 19.4 (7.6) | −0.04 | 17.1 (6.2) | 18.5 (7.1) | −0.21 |
PVPI | 3.5 (1.5) | 3.1 (1.2) | 0.29 | 3.3 (1.3) | 3.4 (1.3) | −0.08 | 3.0 (0.98) | 3.5 (1.5) | −0.39 |
Corticosteroid use | 38 (43.7) | 26 (33.8) | 0.20 | 62 (38.3) | 69 (41.3) | −0.06 | 12 (41.9) | 10 (32.3) | 0.20 |
Catecholamine use | 58 (66.7) | 59 (76.6) | −0.22 | 117 (72.2) | 113 (67.7) | 0.10 | 23 (74.2) | 23 (74.2) | 0.00 |
Renal replacement therapy | 25 (28.7) | 18 (23.4) | 0.12 | 45 (27.8) | 50 (30.1) | −0.05 | 9 (29.0) | 6 (19.4) | 0.23 |
Diuretic use | 43 (49.4) | 38 (49.4) | 0.00 | 75 (46.6) | 84 (50.3) | −0.07 | 16 (51.6) | 13 (41.9) | 0.20 |
PMX use | 12 (13.8) | 6 (7.6) | 0.20 | 18 (11.1) | 14 (8.4) | 0.09 | 4 (12.9) | 1 (3.2) | 0.36 |