|
Patient characteristic
|
Unadjusted groups
|
IPTW Groups
|
Matched groups
|
|---|
|
Sivelestat (n = 87)
|
Control (n = 77)
|
Standardized difference
|
Sivelestat (n = 162)
|
Control (n = 167)
|
Standardized difference
|
Sivelestat (n = 31)
|
Control (n = 31)
|
Standardized difference
|
|---|
|
Age, year
|
66.1 (17.5)
|
65.9 (16.2)
|
0.01
|
67.7 (16.2)
|
69.0 (15.8)
|
−0.08
|
69.8 (15.6)
|
67.3 (15.3)
|
0.16
|
|
Male sex
|
57 (65.5)
|
50 (64.9)
|
0.01
|
104 (64.2)
|
114 (68.3)
|
−0.09
|
21 (67.7)
|
19 (61.3)
|
0.13
|
|
Academic hospital
|
49 (56.3)
|
48 (63.3)
|
−0.14
|
92 (56.8)
|
86 (51.8)
|
0.10
|
20 (64.5)
|
15 (48.4)
|
0.33
|
|
Hospital volume (cases)
| | | | | | | | | |
|
Low (1–10)
|
37 (42.5)
|
43 (55.8)
|
−0.27
|
73 (45.1)
|
70 (41.9)
|
0.06
|
15 (48.4)
|
14 (45.2)
|
0.06
|
|
Medium (11–20)
|
19 (21.8)
|
18 (23.4)
|
−0.04
|
32 (19.8)
|
34 (20.4)
|
−0.01
|
8 (25.8)
|
5 (16.1)
|
0.28
|
|
High (≥21)
|
31 (35.6)
|
16 (20.8)
|
0.33
|
57 (35.2)
|
63 (37.7)
|
−0.05
|
8 (25.8)
|
12 (38.7)
|
−0.28
|
|
Direct lung injury
|
54 (62.1)
|
44 (57.1)
|
0.10
|
94 (58.4)
|
104 (62.3)
|
−0.08
|
19 (61.3)
|
21 (67.7)
|
−0.13
|
|
APACHE II
|
22.2 (7.4)
|
23.5 (7.4)
|
−0.18
|
23.5 (7.3)
|
23.3 (7.5)
|
0.03
|
23.7 (5.5)
|
24.0 (7.6)
|
−0.05
|
|
SOFA score
|
10.1 (3.3)
|
11.2 (3.6)
|
−0.32
|
10.7 (3.3)
|
10.6 (3.7)
|
0.03
|
10.8 (3.3)
|
10.0 (3.2)
|
0.25
|
|
SIRS score
|
2.3 (1.0)
|
2.4 (1.2)
|
−0.09
|
2.4 (1.1)
|
2.4 (1.1)
|
0.00
|
2.4 (1.2)
|
2.5 (1.1)
|
−0.09
|
|
MAP, mmHg
|
75.5 (18.3)
|
77.2 (15.5)
|
−0.10
|
77.3 (19.1)
|
78.8 (17.2)
|
−0.08
|
75.8 (20.1)
|
73.9 (14.3)
|
0.11
|
|
CVP, mmHg
|
10.7 (5.4)
|
9.3 (5.2)
|
0.26
|
9.8 (5.2)
|
9.7 (5.1)
|
0.02
|
10.5 (4.7)
|
9.5 (5.8)
|
0.19
|
|
Fluid balance on Day 0, mL
|
2,239 (2,228)
|
1,498 (1,640)
|
0.38
|
1,915 (1,977)
|
1,861 (1,686)
|
0.03
|
1,495 (2,267)
|
1,673 (2,333)
|
−0.08
|
|
PaO2/FiO2
|
148.5 (73.1)
|
148.4 (65.6)
|
0
|
142.9 (70.2)
|
145.6 (63.9)
|
−0.04
|
141.7 (71.1)
|
128.5 (60.2)
|
0.20
|
|
PEEP, cm/H2O
|
8.4 (4.9)
|
8.3 (4.1)
|
0.02
|
8.2 (4.6)
|
8.1 (3.8)
|
0.02
|
8.1 (5.0)
|
8.8 (4.6)
|
−0.15
|
|
Cardiac index, L/m2
|
3.5 (1.4)
|
3.5 (1.2)
|
0
|
3.4 (1.4)
|
3.4 (1.1)
|
0.00
|
3.7 (1.5)
|
3.2 (1.0)
|
0.39
|
|
GEDI, mL/m2
|
836.9 (236.4)
|
784.2 (158.0)
|
0.26
|
809.9 (208.4)
|
805.2 (149.3)
|
0.03
|
805.9 (167.5)
|
761.9 (150.1)
|
0.28
|
|
EVLWi, mL/kg
|
20.0 (7.1)
|
17.2 (6.4)
|
0.41
|
19.1 (6.4)
|
19.4 (7.6)
|
−0.04
|
17.1 (6.2)
|
18.5 (7.1)
|
−0.21
|
|
PVPI
|
3.5 (1.5)
|
3.1 (1.2)
|
0.29
|
3.3 (1.3)
|
3.4 (1.3)
|
−0.08
|
3.0 (0.98)
|
3.5 (1.5)
|
−0.39
|
|
Corticosteroid use
|
38 (43.7)
|
26 (33.8)
|
0.20
|
62 (38.3)
|
69 (41.3)
|
−0.06
|
12 (41.9)
|
10 (32.3)
|
0.20
|
|
Catecholamine use
|
58 (66.7)
|
59 (76.6)
|
−0.22
|
117 (72.2)
|
113 (67.7)
|
0.10
|
23 (74.2)
|
23 (74.2)
|
0.00
|
|
Renal replacement therapy
|
25 (28.7)
|
18 (23.4)
|
0.12
|
45 (27.8)
|
50 (30.1)
|
−0.05
|
9 (29.0)
|
6 (19.4)
|
0.23
|
|
Diuretic use
|
43 (49.4)
|
38 (49.4)
|
0.00
|
75 (46.6)
|
84 (50.3)
|
−0.07
|
16 (51.6)
|
13 (41.9)
|
0.20
|
|
PMX use
|
12 (13.8)
|
6 (7.6)
|
0.20
|
18 (11.1)
|
14 (8.4)
|
0.09
|
4 (12.9)
|
1 (3.2)
|
0.36
|
- Number of patients (n) in the IPTW groups was an estimated number determined by weighting inversed probability (propensity score).
- APACHE, acute physiology and chronic health evaluation, CVP, central venous pressure, EVLWi, extravascular lung water index, GEDI, global end-diastolic volume index, IPTW, inverse probability of treatment weighting, PEEP, positive end-expiratory pressure, PMX, polymyxin B hemoperfusion, PVPI, pulmonary vascular permeability index, SIRS, systemic inflammatory response syndrome, SOFA, sequential organ failure assessment.
