Figure 2

Arterial oxygen pressure, A-aDO ₂ , Evans blue dye (EBD) extravasation, and the lung dry/wet weight ratio. (A) Arterial oxygen pressure (PaO₂), (B) alveolar-arterial oxygen difference (A-aDO₂), (C) EBD extravasation, an estimate of protein permeability, (D) the lung dry-to-wet (dry/wet) weight ratio, an estimate of the lung water content. LV low tidal volume (6 ml/kg), HV high tidal volume (35 ml/kg), SAL saline, TM thrombomodulin. 0 h, baseline measurement (tidal volume of 6 ml/kg) before the assignment of experimental tidal volume; 0.5, 1, 1.5, and 2 h, hours after the assignment of experimental tidal volume (6 ml/kg or 35 ml/kg). Bars indicate mean ± SE. *P < 0.05 versus the respective LV groups. #P < 0.05 versus the HV/SAL group. n = number of rats.