Figure 2
From: Thrombomodulin/activated protein C system in septic disseminated intravascular coagulation
Anti-inflammatory and cytoprotective functions of TM/APC. HMGB1, high-mobility group box 1; PAR1, protease-activated receptor-1; S1P1, sphingosine 1-phosphate receptor; TAFIa, active thrombin-activatable fibrinolysis inhibitor; EPCR, endothelial cell protein C receptor; ERK, extracellular signal-regulated kinase; NF-κB, nuclear factor-κ B; Ang1, angiopoietin 1; Tie2, tyrosine kinase with Ig-like loops and epidermal growth factor homology domains-2, ApoER2, apolipoprotein E receptor 2; Dab1, disabled-1; PAMPs, pathogen-associated molecular patterns; DAMPs, damage-associated molecular patterns.