| |
Sepsis (n = 11)
|
Severe sepsis without shock (n = 12)
|
Septic shock (n = 24)
|
p value
|
|---|
|
Age (year)
|
70.6 ± 13.7
|
65.2 ± 19.0
|
67.8 ± 15.3
|
0.716
|
|
Gender, n (%)
| | | |
0.058
|
|
Male
|
5 (45.5)
|
11 (91.7)
|
16 (66.7)
| |
|
Female
|
6 (54.5)
|
1 (8.3)
|
8 (33.3)
| |
|
BMI, kg/m2
|
21.6 (18.4,24.1)
|
20.6 (20.1,21.7)
|
23.9 (20.5,28.8)
|
0.090
|
|
Concomitant disease, n (%)
| | | | |
|
Diabetes mellitus
|
3 (27.3)
|
6 (50.0)
|
9 (37.5)
|
0.531
|
|
Hypertension
|
5 (45.5)
|
3 (25.0)
|
12 (50.0)
|
0.351
|
|
CKD
|
4 (36.4)
|
2 (16.7)
|
13 (54.2)
|
0.001
|
|
CPB duration, min
|
102.0 ± 129.4
|
187.5 ± 134.8
|
245.6 ± 133.4
|
0.017
|
|
Aortic cross clamping, min
|
69.4 ± 92.4
|
108.8 ± 84.2
|
107.8 ± 111.4
|
0.542
|
|
Operation time, min
|
418.5 ± 136.1
|
540.8 ± 121.7
|
534.5 ± 231.9
|
0.206
|
|
Blood loss, mL
|
802 (398,2489)
|
6790 (1364,8324)
|
2530 (1227,4961)
|
0.019
|
|
APACHE II
|
15.5 ± 6.1
|
16.8 ± 7.6
|
23.5 ± 6.2
|
0.002
|
|
SOFA
|
5.5 ± 1.4
|
5.9 ± 2.9
|
8.2 ± 2.5
|
0.004
|
|
ICU stay, day
|
12.0 (4.0,23.0)
|
13.0 (7.3,24.5)
|
49.5 (17.8,81)
|
0.001
|
|
Hospital stay, day
|
60.9 ± 59.6
|
114.2 ± 85.5
|
124.5 ± 101.0
|
0.152
|
|
30-Day mortality, n (%)
|
0
|
0
|
3 (12.5)
|
0.215
|
|
Hospital mortality, n (%)
|
0
|
0
|
22 (91.7)
|
0.001
|
|
MV duration, h
|
40.0 (16.0,183.0)
|
58.5 (13.5,404.3)
|
992.5 (276.3,1559.3)
|
0.001
|
|
CRRT, n (%)
|
3 (27.3)
|
2 (16.7)
|
21 (87.5)
|
0.001
|
|
PMX-DHP, n (%)
|
0
|
0
|
17 (70.8)
|
0.001
|
|
ECMO, n (%)
|
0
|
1 (8.3)
|
12 (50.0)
|
0.001
|
|
DIC, n (%)
|
0
|
1 (8.3)
|
22 (91.7)
|
0.024
|
|
PCT, ng/mL
|
1.37 (0.72,1.85)
|
3.16 (0.48,13.24)
|
3.68 (1.67,20.96)
|
0.024
|
|
WBC, ×103/μL
|
12.40 (9.10,24.20)
|
13.30 (9.93,16.93)
|
20.40 (13.45,28.6)
|
0.060
|
|
CRP, mg/dL
|
12.00 (7.40,18.00)
|
13.57 (8.17,18.13)
|
17.11 (15.15,30.6)
|
0.009
|
|
Gram positive, n (%)
| | | | |
|
MRSA
|
0
|
0
|
6 (25.0)
|
0.037
|
|
S. epidermidis
|
2 (18.7)
|
4 (33.3)
|
1 (4.2)
|
0.064
|
|
E. faecalia
|
0
|
0
|
3 (12.5)
|
0.215
|
|
C. striatum
|
0
|
0
|
3 (12.5)
|
0.215
|
|
Gram negative, n (%)
| | | | |
|
S. marcescens
|
0
|
2 (16.7)
|
2 (8.3)
|
0.359
|
|
P. aeruginosa
|
1 (9.1)
|
1 (8.3)
|
3 (12.5)
|
0.913
|
|
B. cepacia
|
1 (9.1)
|
1 (8.3)
|
1 (4.2)
|
0.815
|
|
K. pneumoniae
|
1 (9.1)
|
1 (8.3)
|
0
|
0.335
|
|
Candida, n (%)
| | | | |
|
C. albicans
|
4 (36.4)
|
2 (16.7)
|
3 (12.5)
|
0.242
|
|
C. glabrata
|
0
|
0
|
2 (8.3)
|
0.368
|
|
C. parapsilosis
|
0
|
1 (8.3)
|
1 (4.2)
|
0.613
|
|
C. tropicalis
|
1 (9.1)
|
1 (8.3)
|
1 (4.2)
|
0.815
|
- MRSA methicillin-resistant Staphylococcus aureus; for other abbreviations, see Table 1.
