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Table 2 Laboratory tests for DIC

From: Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines

 

Abnormality in DIC

Other cause for the abnormality

Adequate type of DIC

PT

Prolongation

Liver dysfunction, vitamin K deficiency

OF, BL, MB

FDP, D-dimer

Elevation

Venous thromboembolism, operation

BL, NS, OF

Fibrinogen

Reduction

Liver dysfunction

BL, MB

Platelet count

Reduction

Bone marrow disorders

OF, MB, BL, NS

AT/PC

Reduction

Liver dysfunction, capillary leak syndrome

OF

SF/TAT

Elevation

Venous thromboembolism, operation

OF, NS, BL, MS

TM

Elevation

Renal dysfunction, organ failure

OF

VWFpp, PAI-I

Elevation

Organ failure

OF

ADATMTS13

Reduction

Liver dysfunction, thrombotic microangiopathy

OF

APTT

Biphasic waveform

Infection

OF

PPIC

Elevation

Venous thromboembolism, operation

BL, MB

  1. PT, prothrombin time; FDP, fibrinogen and fibrin degradation products; SF, soluble fibrin; AT, antithrombin; PC, protein C; TAT, thrombin AT complex; VWFpp, von Willebrand factor propeptide; PAI-I, plasminogen activator inhibitor-I; APTT, activated partial thromboplastin time; PPIC, plasmin-plasmin inhibitor complex; OF, organ failure type of DIC; BL, bleeding type of DIC; MB, massive bleeding type of DIC; NS, non-symptomatic type of DIC.