Table 4 Pseudomonas aeruginosa type III effector molecules
Effectors | Other names | Genes | PA number | Protein size | Amino acids | Homologous proteins | Activity | Effect on host |
|---|---|---|---|---|---|---|---|---|
ExoS | 49-kDa exoenzyme S | exoS | PA3841 | 49Â kDa | 453 | Yersinia YopE | ADP-ribosyltransferase | Antiphagocytosis |
Salmonella SptP | GAP activity | |||||||
ExoT | 53-kDa exoenzyme S | exoT | PA0044 | 53Â kDa | 457 | Yersinia YopE | GAP activity | Inhibition of wound healing |
Exoenzyme T | Â | Â | Â | Salmonella SptP | ||||
ExoU | PepA | exoU | - | 72Â kDa | 687 | Mammalian cPLA2 | Patatin-like phospholipase | Cell death |
Plant patatins | Â | Acute lung injury | ||||||
Bacteremia, sepsis | ||||||||
ExoY | - | exoY | PA2191 | 42Â kDa | 378 | B. anthoracis EF | Adenylate cyclase | Edema, inhibition of inflammatory cytokine secretion |
| Â | Â | Â | Â | Â | Â | Bordetella CyaA | Â | Â |