Figure 5From: The molecular mechanism of acute lung injury caused by Pseudomonas aeruginosa: from bacterial pathogenesis to host responseThe molecular structure and functional targets of ExoU. P. aeruginosa ExoU, a major factor causing cytotoxicity and epithelial injury in the lung, contains a patatin domain that catalyzes membrane phospholipids through phospholipase A2 activity. Homology in the amino acid sequence, with a catalytic dyad in the primary structure, was found between patatin, mammalian phospholipase A2 (cPLA2-α and iPLA2), and ExoU. FFA free fatty acid.Back to article page