Figure 4
Contact-dependent toxin translocation during type III secretion in Pseudomonas aeruginosa . P. aeruginosa translocates toxins after direct contact with the surface of the target eukaryotic cell. ExoS and ExoT modulate the cytoskeleton and endocytosis through interaction with Ras and/or Rho GTPases; ExoU disrupts the integrity of the lipid membrane by targeting phospholipids; and ExoY causes edema formation by increasing cyclic adenosine monophosphate.